×
MedSchool: Ace Your OSCEsThe Medical Company
 
 
 
 
 
GET - On the App Store
View
Myeloma Screen
 
 

Manifestations of Myeloma

 
 
 
Bookmark

Overview

MGUS and smouldering myeloma by definition do not manifest clinically. Multiple myeloma presents classically with hypercalcaemia, renal dysfunction, anaemia and lytic bony lesions (denoted by the acronym CRAB); myeloma should be suspected in patients with any of these manifestations without any other clear cause.
  • Manifestations of Multiple Myeloma

  • Classical (CRAB)

  • Calcium - hypercalcaemia
  • Renal failure (multifactorial) - due to cast nephropathy, glomerular light chain deposition, hypercalcaemia, amyloidosis
  • Anaemia - normocytic, normochromic
  • Bone lesions - lytic lesions, due to osteoclastic change
  • Other

  • Hyperviscosity syndrome - due to hypergammaglobulinaemia
  • Amyloidosis - GI, cardiac, hepatic, renal, muscular or nerve infiltration
  • Recurrent infections - due to relative hypogammaglobulinaemia
Next Page
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Sign Up Now
   
 
 

Snapshot: Initialising...