×
MedSchool: Ace Your OSCEsThe Medical Company
 
 
 
 
 
GET - On the App Store
View
Viral Infections
 
 

Hepatitis C

 
 
 
Bookmark

Overview

  • Ask About

  • Diagnosis - cause (if known), when diagnosed
  • Manifestations - cirrhosis, lichen planus, cryoglobulinaemia, glomerulonephropathy
  • Management - direct acting antivirals, surveillance
  • Risk Factors for Hepatitis C Infection

  • Certain ethnic groups
  • Children of hepatitis C positive mothers
  • Iatrogenic exposure - surgery, colonoscopy, haemodialysis, blood transfusion prior to 1990
  • Healthcare workers
  • IV drug use
  • Prisoners
  • Tattoos

Manifestations

  • Manifestations of Hepatitis C Infection

  • Hepatic

  • Chronic hepatitis
  • Cirrhosis
  • Extrahepatic

  • Dermatologic - lichen planus, porphyria cutanea tarda
  • Immune - essential mixed cryoglobulinaemia, Sjogren’s syndrome
  • Renal - membranoproliferative glomerulonephropathy
  • Non-Hodgkin lymphoma
  • Type 2 diabetes mellitus

Management

  • Management of Hepatitis C Infection

  • Non-Pharmacologic

  • Cirrhosis surveillance
  • HCC surveillance
  • Pharmacologic

  • NS3/4A inhibitors - grazoprevir, pariteprevir, simepravir
  • NS5A inhibitors - daclatasvir, elbasvir, ledipasvir, ombitasvir
  • NS5B inhibitors - dasabuvir, sofosbuvir

Overview

Serology may be used to assess for active or past infection with hepatitis C.
  • Interpretation

  • Hepatitis C antibody (Anti-HCV) - indicative of past or current (acute or chronic) infection
  • Hepatitis C RNA - indicative of active infection
Next Page
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Sign Up Now