Thyroglobulin
Overview
Thyroglobulin (Tg) is a storage form of the thyroid hormones produced by follicular cells of the thyroid, and is released into serum in conjunction with T3 and T4.
Thyroglobulin (Tg) is not routinely measured in clinical practice.
Clinical Use of Thyroglobulin Testing
- Diagnosis of thyrotoxicosis factitia - used to distinguish surreptitious thyroxine ingestion from other causes of hyperthyroidism, as thyroglobulin will remain normal with exogenous thyroxine use
- Thyroid cancer - assessing for residual tumour post resection, or monitoring for recurrence
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