Thyroid Function
 

Anti-TSH Receptor Antibodies

 
 
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Overview

  • TSH receptor antibodies are directed against TSH receptors on thyroid follicular cells. In Grave's disease these antibodies bind to TSH receptors and stimulate release of thyroid hormone.
    • Significance

    • Presence of anti-TSH receptor antibodies is pathognomonic of Grave's disease.
  • Diagnosis of Grave's disease is usually made clinically in patients with overt manifestations of Grave's such as ophthalmopathy.
  • TSH receptor antibodies are a useful test for determining the cause of hyperthyroidism in patients without clear features of Grave's.
 
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