Uric Acid | Renal Function - MedSchool
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Renal Function
 
 
 

Uric Acid

 
 
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Overview

      • Normal Range

      • 3.0 - 8.0 mg/dL

Hyperuricaemia

  • It is important to note that while hyperuricaemia predisposes to gout and nephrolithiasis, its presence does not indicate the presence of these conditions.
    • Causes of Hyperuricaemia

    • Increased Production

    • Diet - purines (liver, kidney, anchovies, mussels, bacon, veal, venison), ethanol, fructose
    • Haematologic - leukaemia, lymphoma, polycythaemia
    • Drugs - cytotoxic drugs, exogenous B12
    • Obesity
    • Psoriasis
    • Hypertriglyceridaemia
    • Reduced Excretion

    • Drugs - cytotoxics, diuretics, pyrazinamide, ethambutol, aspirin
    • Renal - hypertension, polycystic kidneys, CKD
    • Metabolic - dehydration, lactic acidosis, ketosis, hypothyroidism, hyperparathyroidism
    • Obesity
    • Sarcoidosis
    • Pregnancy
Last updated on July 6th, 2018
 
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 Koyner JL. Assessment and diagnosis of renal dysfunction in the ICU. CHEST Journal. 2012 Jun 1;141(6):1584-94. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J. A new equation to estimate glomerular filtration rate. Annals of internal medicine. 2009 May 5;150(9):604-12. Nankivell BJ. Creatinine Clearance and the Assessment of Renal Function. Australian Prescriber. 2001; 24: 15-17. Richards RJ, Donica MB, Grayer D. Can the Blood Urea Nitrogen/Creatinine Ratio Distinguish Upper From Lower Gastrointestinal Bleeding?. Journal of clinical gastroenterology. 1990 Oct 1;12(5):500-4. Samra M, Abcar AC. False estimates of elevated creatinine. The Permanente Journal. 2012;16(2):51. Schold JD, Navaneethan SD, Jolly SE, Poggio ED, Arrigain S, Saupe W, Jain A, Sharp JW, Simon JF, Schreiber MJ, Nally JV. Implications of the CKD-EPI GFR estimation equation in clinical practice. Clinical Journal of the American Society of Nephrology. 2011 Mar 1;6(3):497-504. Shlipak MG, Katz R, Kestenbaum B, Fried LF, Newman AB, Siscovick DS, Stevens L, Sarnak MJ. Rate of kidney function decline in older adults: a comparison using creatinine and cystatin C. American journal of nephrology. 2009;30(3):171-8.
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