Renal Function

Measured Creatinine Clearance



  • Measured creatinine clearance is an estimate of the GFR based on a 24-hour urine sample. It was previously more popular and is now not often used in clinical practice due to newer eGFR formulae that are based on serum creatinine.
    • Formula

    • Creatinine clearance = (urine creatinine x volume) / serum creatinine
    • Limitations

    • Tends to overestimate GFR, as 15% of creatinine is actively secreted into the tubules.
Last updated on August 9th, 2018
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge


 Bellomo R, Kellum JA, Ronco C. Acute kidney injury. The Lancet. 2012 Aug 31;380(9843):756-66.
Harris MD, Siegel LB, Alloway JA. Gout and hyperuricemia. American family physician. 1999 Feb;59(4):925-34.
 Koyner JL. Assessment and diagnosis of renal dysfunction in the ICU. CHEST Journal. 2012 Jun 1;141(6):1584-94. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J. A new equation to estimate glomerular filtration rate. Annals of internal medicine. 2009 May 5;150(9):604-12. Nankivell BJ. Creatinine Clearance and the Assessment of Renal Function. Australian Prescriber. 2001; 24: 15-17. Richards RJ, Donica MB, Grayer D. Can the Blood Urea Nitrogen/Creatinine Ratio Distinguish Upper From Lower Gastrointestinal Bleeding?. Journal of clinical gastroenterology. 1990 Oct 1;12(5):500-4. Samra M, Abcar AC. False estimates of elevated creatinine. The Permanente Journal. 2012;16(2):51. Schold JD, Navaneethan SD, Jolly SE, Poggio ED, Arrigain S, Saupe W, Jain A, Sharp JW, Simon JF, Schreiber MJ, Nally JV. Implications of the CKD-EPI GFR estimation equation in clinical practice. Clinical Journal of the American Society of Nephrology. 2011 Mar 1;6(3):497-504. Shlipak MG, Katz R, Kestenbaum B, Fried LF, Newman AB, Siscovick DS, Stevens L, Sarnak MJ. Rate of kidney function decline in older adults: a comparison using creatinine and cystatin C. American journal of nephrology. 2009;30(3):171-8.
Traynor J, Mactier R, Geddes CC, Fox JG. How to measure renal function in clinical practice. BMJ: British Medical Journal. 2006 Oct 7;333(7571):733.