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Renal Function
 
 

Estimated Glomerular Filtration Rate (eGFR)

 
 
 
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Overview

eGFR is the most common means for estimating glomerular filtration rate (GFR) in clinical practice in the context of assessing chronic kidney disease; equations rely on serum creatinine measurements and are adjusted depending on the patient's demographic information.
eGFR calculators can be found in the tools section of the app.
  • Stages of Chronic Kidney Disease

  • StageeGFR (ml/min/1.73 m²)
    I ≥90
    I60 - 89
    III30 - 59
    IV15 - 29
    V<15

MDRD Formula

The MDRD formula was created for the modification of diet in renal disease (MDRD) study based on data from patients with advanced renal failure. This formula is commonly used by labs to calculate an eGFR to be reported along with the creatinine.
  • Formula

  • eGFR = 186.3 × Creatinine-1.154 × Age-0.203 ( × 0.742 if female) ( × 1.212 if African origin)
There are also five-variable (including BUN) and six-variable (including albumin) MDRD formulae for eGFR.
  • Limitations

  • Not validated for patients with normal renal function
  • Not validated for acute kidney injury and for patients with rapidly changing renal function, as the data is from CKD
  • Not accurate in pregnancy, severe malnutrition and in children

CKD-EPI Formula

Uses the same variables as the MDRD formula but with a slightly different equation that tends to be more predictive, especially at higher GFRs.
  • Formula

  • eGFR = 141 × (Creatinine/X)Y × 0.993Age ( × 1.018 if female) ( × 1.159 if african origin)

    Female:
       Cr ≤0.7mg/dL (62µmol/L): X = 0.7; Y = -0.329
       Cr >0.7mg/dL (62µmol/L): X = 0.7; Y = -1.209
    Male:
       Cr ≤0.9mg/dL (80µmol/L): X = 0.9; Y = -0.411
       Cr >0.9mg/dL (80µmol/L): X = 0.9; Y = -1.209
  • Limitations

  • Younger patients are more likely to have a higher eGFR and be classified in lower stages of CKD compared to other formulae
  • Older patients (>80 years) are more likely to have a lower eGFR and be classified in higher stages of CKD compared to other formulae
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