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Renal Function

Creatinine Clearance

October 29th, 2020


Measured creatinine clearance is an estimate of the GFR based on a 24-hour urine sample. It was previously more popular and is now not often used in clinical practice due to newer eGFR formulae that are based on serum creatinine.
  • Formula

  • Creatinine clearance = (urine creatinine x volume) / serum creatinine
  • Limitations

  • Tends to overestimate GFR, as 15% of creatinine is actively secreted into the tubules.
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