Overview
A copper-containing protein produced by the liver that binds ~90% of plasma copper.
Caeruloplasmin is an acute phase reactant.
Significance
- Used as a test for Wilson's disease, in conjunction with serum copper concentration.
Reduced Caeruloplaemin
Causes of Reduced Caeruloplasmin
- Wilson's disease
- Reduced synthesis - liver disease, malnutrition, malabsorption, TPN
- Increased loss - nephrotic syndrome, protein-losing enteropathy, Menke's disease
Elevated Caeruloplasmin
Causes of Elevated Caeruloplasmin
- Acute phase reaction - infection, inflammation, malignancy
- Endocrine - pregnancy, hormone replacement
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