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Liver Function Tests
 
Liver Function Tests
 

Caeruloplasmin

 
 
 
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Overview

A copper-containing protein produced by the liver that binds ~90% of plasma copper.
Caeruloplasmin is an acute phase reactant.
  • Significance

  • Used as a test for Wilson's disease, in conjunction with serum copper concentration.

Reduced Caeruloplaemin

  • Causes of Reduced Caeruloplasmin

  • Wilson’s disease
  • Reduced synthesis - liver disease, malnutrition, malabsorption, TPN
  • Increased loss - nephrotic syndrome, protein-losing enteropathy, Menke’s disease

Elevated Caeruloplasmin

  • Causes of Elevated Caeruloplasmin

  • Acute phase reaction - infection, inflammation, malignancy
  • Endocrine - pregnancy, hormone replacement
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