Liver Function Tests
 

Caeruloplasmin

 
 
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Overview

  • A copper-containing protein produced by the liver that binds ~90% of plasma copper.
  • Caeruloplasmin is an acute phase reactant.
    • Significance

    • Used as a test for Wilson's disease, in conjunction with serum copper concentration.

Reduced Caeruloplaemin

    • Causes of Reduced Caeruloplasmin

    • Wilson’s disease
    • Reduced synthesis - liver disease, malnutrition, malabsorption, TPN
    • Increased loss - nephrotic syndrome, protein-losing enteropathy, Menke’s disease

Elevated Caeruloplasmin

    • Causes of Elevated Caeruloplasmin

    • Acute phase reaction - infection, inflammation, malignancy
    • Endocrine - pregnancy, hormone replacement
 
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