Albumin
Overview
- Albumin is a group of serum proteins produced by the liver that maintain oncotic pressure and transport certain hydrophobic compounds.
Normal Range
- 32 - 45 g/L
- Albumin has a plasma half-life of three weeks, meaning that its concentration changes very slowly in response to changes in synthesis.
Hypoalbuminaemia
- A reduction in serum albumin may occur due to reduced production, increased proteolysis (protein breakdown) or increased loss.
- As albumin is essential for the maintenance of oncotic pressure, hypoalbuminaemia may manifest with widespread oedema.
Causes of Hypoalbuminaemia
- Reduced synthesis - malnutrition, malabsorption, liver disease
- Increased breakdown - infection, inflammation, malignancy, hyperthyroidism
- Increased loss - nephrotic syndrome, protein-losing enteropathy, severe burns
- Dilutional
Hyperalbuminaemia
- Increased serum albumin is uncommon, and strongly suggests dehydration.
Last updated on September 12th, 2020
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