Liver Function Tests
 

Albumin

 
 
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Overview

  • Albumin is a group of serum proteins produced by the liver that maintain oncotic pressure and transport certain hydrophobic compounds.
      • Normal Range

      • 32 - 45 g/L
  • Albumin has a plasma half-life of three weeks, meaning that its concentration changes very slowly in response to changes in synthesis.

Hypoalbuminaemia

  • A reduction in serum albumin may occur due to reduced production, increased proteolysis (protein breakdown) or increased loss.
  • As albumin is essential for the maintenance of oncotic pressure, hypoalbuminaemia may manifest with widespread oedema.
    • Causes of Hypoalbuminaemia

    • Reduced synthesis - malnutrition, malabsorption, liver disease
    • Increased breakdown - infection, inflammation, malignancy, hyperthyroidism
    • Increased loss - nephrotic syndrome, protein-losing enteropathy, severe burns
    • Dilutional

Hyperalbuminaemia

  • Increased serum albumin is uncommon, and strongly suggests dehydration.
Last updated on September 12th, 2020
 
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