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Iron Studies

Transferrin Saturation

April 30th, 2020


The transferrin saturation (TSat) is the percentage of transferrin that is bound to iron. This is a more accurate measure of total body iron than the serum iron concentration, which fluctuates significantly.
    • Normal Range

    • Males: 15 - 45%
    • Females: 15 - 55%

Elevated Transferrin Saturation

High transferrin saturation is an indicator of iron overload.
  • Causes of Elevated Transferrin Saturation

  • Acute iron intake
  • Iron overload

Reduced Transferrin Saturation

Reduced transferrin saturation is a marker of iron deficiency, though can also occur in chronic disease; the ferritin is unlikely to be reduced in the latter.
  • Causes of Reduced Transferrin Saturation

  • Iron deficiency
  • Chronic disease - infection, inflammation, malignancy
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