Transferrin Saturation
April 30th, 2020
Overview
The transferrin saturation (TSat) is the percentage of transferrin that is bound to iron. This is a more accurate measure of total body iron than the serum iron concentration, which fluctuates significantly.
Normal Range
- Males: 15 - 45%
- Females: 15 - 55%
Elevated Transferrin Saturation
High transferrin saturation is an indicator of iron overload.
Causes of Elevated Transferrin Saturation
- Acute iron intake
- Iron overload
Reduced Transferrin Saturation
Reduced transferrin saturation is a marker of iron deficiency, though can also occur in chronic disease; the ferritin is unlikely to be reduced in the latter.
Causes of Reduced Transferrin Saturation
- Iron deficiency
- Chronic disease - infection, inflammation, malignancy
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