Transferrin | Iron Studies - MedSchool
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Iron Studies
 
 
Iron Studies
Transferrin is an transport protein that binds to iron in plasma.
 

Transferrin

 
 

Overview

  • Transferrin is an transport protein that binds to iron in plasma.
      • Normal Range

      • 1.5 - 3.2 g/L
  • Total iron binding capacity (TIBC) is the total amount of iron that can be bound to serum transferrin, and as such the TIBC is proportional to the transferrin level.

Elevated Transferrin

  • Elevated transferrin levels is a marker of iron deficiency.

Reduced Transferrin

  • Reduced transferrin levels may occur in the setting of an acute phase response or chronic disease. Iron overload may produce a normal or reduced transferrin level.
Last updated on January 13th, 2020
 
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 Andres E, Serraj K, Zhu J, Vermorken AJ. The pathophysiology of elevated vitamin B12 in clinical practice. QJM: An International Journal of Medicine. 2013 Jun 1;106(6):505-15. Baik HW, Russell RM. Vitamin B12 deficiency in the elderly. Annu Rev Nutr. 1999;19:357-377. Benz Jr EJ. Iron Loading Anaemia. eLS. Brugnara C. Iron Deficiency and Erythropoiesis: New Diagnostic Approaches. Clinical Chemistry. 2003; 49(10): 1573-1578. Cook JD, Flowers CH, Skikne BS. The quantitative assessment of body iron. Blood. 2003; 101: 3359-3363. Goot K, Hazeldine S, Bentley P, Olynyk J, Crawford D. Elevated serum ferritin: What should GPs know?. Australian family physician. 2012;41(12):945-9. Kelly AU, McSorley ST, Patel P, Talwar D. Interpreting iron studies. BMJ: British Medical Journal. 2017 Jun 15;357. Lieu PT, Heiskala M, Peterson PA, Yang Y. The roles of iron in health and disease. Molecular aspects of medicine. 2001 Feb 1;22(1-2):1-87. Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L. Iron deficiency anaemia. The Lancet. 2016 Feb 27;387(10021):907-16.
Metz J. Appropriate use of tests for folate and vitamin B12 deficiency. Australian Prescriber. 1999 Feb 1;22(1):16-8.
Muñoz M, Villar I, García-Erce JA. An update on iron physiology. World journal of gastroenterology: WJG. 2009 Oct 7;15(37):4617.
 Neumann WL, Coss E, Rugge M, Genta RM. Autoimmune atrophic gastritis--pathogenesis, pathology and management. Nat Rev Gastroenterol Hepatol. 2013;10(9):529-541. Rossi E. Hepcidin-the iron regulatory hormone. Clinical Biochemist Reviews. 2005 Aug;26(3):47. Snow CF. Laboratory diagnosis of vitamin B12 and folate deficiency: a guide for the primary care physician. Archives of internal medicine. 1999 Jun 28;159(12):1289-98. Stabler SP. Vitamin B12 deficiency. New England Journal of Medicine. 2013 Jan 10;368(2):149-60. Stanger O. Physiology of folic acid in health and disease. Current drug metabolism. 2002 Apr 1;3(2):211-23. Van Vranken M. Evaluation of microcytosis. American family physician. 2010 Nov 1;82(9). VanWagner LB, Green RM. Elevated serum ferritin. Jama. 2014 Aug 20;312(7):743-4. Waldvogel-Abramowski S, Waeber G, Gassner C, Buser A, Frey BM, Favrat B, Tissot JD. Physiology of iron metabolism. Transfusion Medicine and Hemotherapy. 2014;41(3):213-21.
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