Haemolytic Screen
 

Reticulocytes

 
 
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Overview

  • Reticulocytes are non-nucleated immature red blood cells.
      • Normal Range

      • Absolute reticulocyte count: 50 - 100 x 10‎⁹/L
      • Reticulocyte percentage: 0.5 - 2.5%

Reticulocytosis

    • Significance

    • Elevated reticulocytes are indicative of compensatory erythropoiesis due to haemolysis, recovery from anaemia or increased red blood cell requirement.
    • Causes of Reticulocytosis

    • Haemolytic anaemia
    • Haemorrhage (acute or chronic)
    • Recovery post bone marrow suppression
    • Late pregnancy
    • High altitude

Reduced Reticulocytes

  • Examination of multiple fields may be required to diagnose a low reticulocyte count.
    • Significance

    • Near absence of reticulocytes is caused by bone marrow suppression, e.g. due to aplastic anaemia or cytotoxic chemotherapy.
 
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