Intravascular Haemolysis
January 20th, 2018
Overview
Markers of Intravascular Haemolysis
- Elevated plasma free haemoglobin
- Elevated urine haemoglobin - urine dipstick positive for blood but no RBC
- Elevated urine haemosiderin - brownish urine due to excess iron stored as haemosiderin
Causes of Intravascular Haemolysis
- Microangiopathic haemolytic anaemia - TTP, HUS, DIC, preeclampsia / HELLP, SLE, malignant hypertension, severe burns, brown snake bite
- Intravascular trauma - valvular leaks, cardiac prostheses, renal replacement, ECMO, march haemoglobinuria
- Alloimmune haemolysis - transfusion of mismatched red blood cells, haemolytic disease of the newborn, post stem cell transplant
- Infection - severe malaria, Clostridium toxin
- Copper (Wilson's disease)
- Certain cold agglutinin haemolysis disorders
- Paroxysmal nocturnal haemoglobinuria
- G6PD deficiency
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