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Haemolytic Screen


January 28th, 2018


Haptoglobin is an alpha-2 glycoprotein secreted mainly by the liver that binds plasma free haemoglobin following red cell lysis, and as such is reduced in the presence of haemolysis (particularly intravascular haemolysis).
    • Normal Range

    • 36 - 195 mg/dL

Increased Haptoglobin

Haptoglobin is an acute phase reactant, and as such will be increased in the presence of infection, inflammation or malignancy.
  • Causes of Increased Haptoglobin

  • Infection
  • Inflammation
  • Malignancy
  • Trauma (including surgery)

Reduced Haptoglobin

Reduced haptoglobin may be caused by reduced production due to liver disease, or by increased consumption due to haemolysis.
  • Causes of Reduced Haptoglobin

  • Haemolysis
  • Chronic liver disease
  • Congenital deficiency
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