Haemolytic Screen
 

Haptoglobin

 
 
Bookmark

Overview

  • Haptoglobin is an alpha-2 glycoprotein secreted mainly by the liver that binds plasma free haemoglobin following red cell lysis, and as such is reduced in the presence of haemolysis (particularly intravascular haemolysis).
      • Normal Range

      • 36 - 195 mg/dL

Increased Haptoglobin

  • Haptoglobin is an acute phase reactant, and as such will be increased in the presence of infection, inflammation or malignancy.
    • Causes of Increased Haptoglobin

    • Infection
    • Inflammation
    • Malignancy
    • Trauma (including surgery)

Reduced Haptoglobin

  • Reduced haptoglobin may be caused by reduced production due to liver disease, or by increased consumption due to haemolysis.
    • Causes of Reduced Haptoglobin

    • Haemolysis
    • Chronic liver disease
    • Congenital deficiency
Last updated on January 28th, 2018
 
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Explore
   
 
 

Read More...

 Bain BJ. Diagnosis from the blood smear. New England Journal of Medicine. 2005 Aug 4;353(5):498-507. Barcellini W, Fattizzo B. Clinical applications of hemolytic markers in the differential diagnosis and management of hemolytic anemia. Disease markers. 2015 Dec 27;2015. Choi JW, Pai SH. Change in erythropoiesis with gestational age during pregnancy. Annals of hematology. 2001 Feb 16;80(1):26-31. Drent M, Cobben NA, Henderson RF, Wouters EF, van Dieijen-Visser M. Usefulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammation. European Respiratory Journal. 1996 Aug 1;9(8):1736-42. Gorst DW, Rawlinson VI, Merry AH, Stratton F. Positive direct antiglobulin test in normal individuals. Vox sanguinis. 1980 Feb 1;38(2):99-105. Lurie S, Mamet Y. Red blood cell survival and kinetics during pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2000 Dec 31;93(2):185-92. Maekawa M. Lactate dehydrogenase isoenzymes. Journal of Chromatography B: Biomedical Sciences and Applications. 1988 Jul 29;429:373-98. Marchand A, Galen RS, Van Lente F. The predictive value of serum haptoglobin in hemolytic disease. Jama. 1980 May 16;243(19):1909-11. Papadopoulos NM. Clinical applications of lactate dehydrogenase isoenzymes. Annals of Clinical & Laboratory Science. 1977 Nov 1;7(6):506-10. Parker V, Tormey CA. The Direct Antiglobulin Test: Indications, Interpretation, and Pitfalls. Archives of Pathology & Laboratory Medicine. 2017 Feb;141(2):305-10. Shih AW, McFarlane A, Verhovsek M. Haptoglobin testing in hemolysis: measurement and interpretation. American journal of hematology. 2014 Apr 1;89(4):443-7.
Tabbara IA. Hemolytic anemias: diagnosis and management. Medical Clinics of North America. 1992 May 1;76(3):649-68.
 Ucar K. Clinical presentation and management of hemolytic anemias. Oncology. 2002 Sep 16;16(9; SUPP/10):163-70. Zantek ND, Koepsell SA, Tharp DR, Cohn CS. The direct antiglobulin test: a critical step in the evaluation of hemolysis. American journal of hematology. 2012 Jul 1;87(7):707-9.
Feedback