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Full Blood Count
 
Full Blood Count
 

Red Cell Count

 
 
 
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Overview

Reflects the number of circulating red blood cells.
    • Normal Range

    • Males: 4.3 - 5.7 x 10¹²/L
    • Females: 3.9 - 5.0 x 10¹²/L

Reduced Red Cell Count

Reduced circulating red blood cells.
  • Causes of Reduced Red Cell Count

  • Reduced RBC Production

  • Haematinic deficiency - B12, folate, iron
  • Bone marrow pathology - aplastic anaemia, myeloproliferative diseases, myelofibrosis
  • Endocrine - EPO deficiency, hypothyroidism
  • Anaemia of chronic disease (infection / inflammation / malignancy)
  • Sideroblastic anaemia
  • Thalassaemias
  • Increased RBC Destruction (Haemolysis)

  • Immune haemolysis - autoimmune, alloimmune, drug-induced
  • Red cell fragmentation - thrombotic microangiopathies, mechanical haemolysis
  • Intrinsic RBC disorders - enzymopathies, membranopathies, haemoglobinopathies
  • Hypersplenism
  • Other - infection, copper, lead, hypophosphataemia
  • RBC Loss

  • Trauma
  • Gastrointestinal bleed
  • Bleeding from another source e.g. urinary tract
  • Factitious

  • Dilutional - excess fluid administration, pregnancy

Elevated Red Cell Count

Increased circulating red blood cells.
  • Causes of Erythrocytosis

  • Primary

  • Primary familial erythrocytosis (EPO receptor mutation)
  • Polycythaemia vera (JAK2 mutation)
  • Secondary

  • Chronic hypoxia - smoking, chronic lung disease, obstructive sleep apnoea, high altitude
  • Renal hypoxia - renal artery stenosis, polycystic kidney disease, post renal transplant
  • Drugs - testosterone, anabolic steroids, erythropoietin
  • Paraneoplastic syndrome (EPO-producing tumour)
  • Congenital - haemoglobinopathies, other mutations
  • Idiopathic
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