Overview
Eosinophils are granulocytes with a bilobed nucleus, blue cytoplasm and orange-red cytoplasmic granules
Normal Range
- 0.0 - 0.5 x 10⁹/L
- 1 - 4% of total leukocytes
Eosinophilia
Eosinophilia refers to an increase in circulating eosinophils.
Causes of Eosinophilia
- Allergy - asthma, allergic rhinitis, chronic sinusitis, atopic dermatitis, eosinophilic oesophagitis, allergic bronchopulmonary aspergillosis (ABPA), chronic eosinophilic pneumonia
- Drug hypersensitivity - e.g. penicillins, cephalosporins, sulpha drugs
- Parasites - helminths (especially Strongyloides), protozoa
- Autoimmune - eosinophilic granulomatosis with polyangiitis (Churg-Strauss), other autoimmune diseases (rarely)
- Malignancy - chronic eosinophilic leukaemia, lymphoma, certain solid organ malignancies
- Primary eosinophilia
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