Overview
Basophils are relatively uncommon white blood cells. Morphologically they are granulocytes with large bluish (basophilic) granules.
Normal Range
- 0.0 - 0.1 x 10⁹/L
- 0.5 - 1% of total leukocytes
Basophilia
Basophilia is the presence of increased numbers of circulating basophils.
Marked basophilia is classically a sign of myeloproliferative neoplasms such as CML.
Causes of Basophilia
- Myeloproliferative neoplasms - chronic myeloid leukaemia, polycythaemia vera, myelofibrosis
- Allergies - asthma, atopic dermatitis, allergic rhinitis
- Inflammation - autoimmune disease, graft vs host disease
- Lymphoma
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