Mean Corpuscular Haemoglobin | Full Blood Count - MedSchool
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Full Blood Count
 

Mean Corpuscular Haemoglobin

 
 

Overview

  • The average amount of haemoglobin per red blood cell.
      • Normal Range

      • 27 - 32pg

Hypochromia

  • Reduced red cell haemoglobin (MCH / MCHC), or increased central pallor on blood film.
    • Causes of Hypochromia

    • Microcytic

    • Iron deficiency anaemia
    • Anaemia of chronic disease (infection / inflammation / malignancy)
    • Thalassaemia
    • Congenital sideroblastic anaemia
    • Lead poisoning
    • Hyperthyroidism
    • Macrocytic

    • Reticulocytosis

Hyperchromia

  • Increased red cell haemoglobin (MCH / MCHC), or reduced central pallor on blood film.
    • Significance

    • Hyperchromic cells may be spherocytes, microspherocytes, macrocytes or sickle cells.
    • Causes of Hyperchromia

    • Spherocytosis - hereditary spherocytosis, immune haemolysis, Clostridium infection
    • Microspherocytosis - microangiopathic haemolytic anaemia, severe burns
    • Macrocytosis - B12/folate deficiency chronic liver disease, alcohol abuse, hypothyroidism, post splenectomy, aplastic anaemia, myelodysplastic syndrome
    • Sickle cells - sickle cell disease
Last updated on January 19th, 2018
 
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