Blood Film
 

Monocytes

 
 
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Overview

  • Monocytes are large leukocytes of myeloid origin with a blue-grey ground glass cytoplasm and an irregularly shaped nucleus. Monocytes often contain vacuoles.
    •  

Monocytosis

  • Increased circulating monocytes.
    • Causes of Monocytosis

    • Chronic infection / inflammation - tuberculosis, EBV, bacterial endocarditis, autoimmune diseases
    • Malignancy - acute myeloid leukaemia, chronic myeloid leukaemia, lymphoma
    • Post splenectomy

Activated Monocytes

  • Monocytes may become activated in the context of infection, inflammation or recovery from bone marrow suppression.
    • Features of Activated Monocytes

    • Increased nuclear : cytoplasmic ratio
    • Cytoplasmic vacuoles
    • Causes of Activated Monocytes

    • Infection
    • Inflammation
    • Malignancy
    • Recovery from bone marrow suppression
    • G-CSF
 
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