Smudge cells
September 8th, 2021
Overview
Smudge cells are remnants of cells, without clear cytoplasmic borders. Such cells are mainly formed when the blood film is made, due to pressure on fragile cells.
Smudge cells are classically a feature of chronic lymphocytic leukaemia (CLL), which manifests with a small mature lymphocytosis and numerous smudge cells. However, several other conditions may result in smudge cells on a blood film.
Causes of Smudge Cells
- Mature lymphocytic leukaemias - e.g. chronic lymphocytic leukaemia, T-large granulocytic leukaemia
- Others - infectious mononucleosis, cardiac arrest
- Artefact - incorrect storage
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