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Blood Film
 
 

Smudge cells

September 8th, 2021
 
 
 
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Overview

Smudge cells are remnants of cells, without clear cytoplasmic borders. Such cells are mainly formed when the blood film is made, due to pressure on fragile cells.
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Smudge cells are classically a feature of chronic lymphocytic leukaemia (CLL), which manifests with a small mature lymphocytosis and numerous smudge cells. However, several other conditions may result in smudge cells on a blood film.
  • Causes of Smudge Cells

  • Mature lymphocytic leukaemias - e.g. chronic lymphocytic leukaemia, T-large granulocytic leukaemia
  • Others - infectious mononucleosis, cardiac arrest
  • Artefact - incorrect storage
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