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Blood Film


February 15th, 2021


Monocytes are large leukocytes of myeloid origin with a blue-grey ground glass cytoplasm and an irregularly shaped nucleus. Monocytes often contain vacuoles.


Increased circulating monocytes.
  • Causes of Monocytosis

  • Chronic infection / inflammation - tuberculosis, EBV, bacterial endocarditis, autoimmune diseases
  • Malignancy - acute myeloid leukaemia, chronic myeloid leukaemia, lymphoma
  • Post splenectomy

Activated Monocytes

Monocytes may become activated in the context of infection, inflammation or recovery from bone marrow suppression.
  • Features of Activated Monocytes

  • Increased nuclear : cytoplasmic ratio
  • Cytoplasmic vacuoles
  • Causes of Activated Monocytes

  • Infection
  • Inflammation
  • Malignancy
  • Recovery from bone marrow suppression
  • G-CSF
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