×
MedSchool: Ace Your OSCEsThe Medical Company
 
 
 
 
 
GET - On the App Store
View
Blood Film
 
 

Hyposplenism on the Blood Film

 
 
 
Bookmark

Overview

Certain characteristic findings on a blood film are suggestive of hyposplenism or asplenism. This may be congenital, iatrogenic (particularly post splenectomy) or associated with acquired medical conditions.
Patients with hyposplenism are at increased risk of infections - particularly with encapsulated bacteria (Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae).
  • Blood Film Findings in Hyposplenism

  • Red Cell Findings

  • Target cells
  • Acanthocytes
  • Howell-Jolly bodies
  • Pappenheimer bodies
  • White Cell Findings

  • Neutrophilia (initially)
  • Lymphocytosis
  • Monocytosis
  • Platelet Findings

  • Thrombocytosis
  • Causes of Hyposplenism

  • Congenital

  • Prematurity
  • Congenital hyposplenism
  • Iatrogenic

  • Post splenectomy
  • High dose steroids
  • Bone marrow transplant
  • Acquired Conditions

  • Vascular - splenic artery / vein thrombosis
  • Haematologic - sickle cell disease, leukaemia, graft vs host disease
  • Gastrointestinal - coeliac disease, inflammatory bowel disease, Whipple’s disease
  • Hepatic - liver cirrhosis, portal hypertension, active chronic hepatitis
  • Autoimmune - SLE, Sjogren’s syndrome rheumatoid arthritis, polyarteritis nodosa
  • Infiltrative - amyloidosis, sarcoidosis
  • Infection - HIV/AIDS
  • Examples

  • Target cells:
  • Target cells
     
  • Howell-Jolly bodies:
  • Howell-Jolly bodies
     
Next Page
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Sign Up Now
   
 
 

Snapshot: Initialising...