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Blood Film

Circulating Plasma Cells

September 8th, 2021


Plasma cells are specialised immune cells derived from B cells which secrete antibodies. They are not usually seen within the peripheral blood except in severe infection and plasma cell dyscrasias.
Morphologically plasma cells are medium-to-large cells with a deep blue cytoplasm and a perinuclear 'hof' (area of pallor adjacent to the nucleus representing the golgi zone).
  • Causes of Circulating Plasma Cells

  • Severe infection / inflammation / malignancy
  • Plasma cell myeloma
  • Plasma cell leukaemia
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Snapshot: Initialising...