Anti-Extractable Nuclear Antigen (ENA)
March 4th, 2023
Overview
Extractable nuclear antigens (ENA) are a subset of antinuclear antibodies (ANA) that are directed against nuclear antigens.
Certain antibodies are particular associated with specific autoimmune disorders.
Lupus & Sjogren's
Anti-SSa / RoSjogren's syndrome, SLE
Anti-SSb / LaSjogren's syndrome, SLE
Anti-Sm (Smith)Highly suggestive of SLE; particularly renal and CNS involvement
Anti-HistoneSLE, drug-induced lupus
Mixed Connective Tissue Disease
Anti-RNPMixed connective tissue disease, scleroderma
Scleroderma
Anti-CentromereLimited scleroderma
Anti-SCL-70 (DNA topoisomerase I)Diffuse scleroderma; increased risk of interstitial lung disease
Anti-RNA polymerase III (RNApol3)Severe cutaneous scleroderma; increased risk of scleroderma renal crisis
Anti-Th/ToScleroderma; increased risk of pulmonary hypertension
Anti-RNPMixed connective tissue disease, scleroderma
Anti-PM-SCLScleroderma / inflammatory myositis crossover
Anti-KuScleroderma / inflammatory myositis crossover
Inflammatory Myositis
Anti-Mi-2Dermatomyositis
Anti-Jo-1Dermatomyositis, antisynthetase syndrome
Anti-HMG CoA reductaseNecrotising myopathy
Anti-MDA5Dermatomyositis with interstitial lung disease
Anti-PM-SCLScleroderma / inflammatory myositis crossover
Anti-KuScleroderma / inflammatory myositis crossover
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