Anti-CCP
September 12th, 2020
Overview
Anti-CCP antibodies are autoantibodies to cyclic citrullinated peptide, which is generally present in rheumatoid arthritis.
Normal Range
- <10 U/mL
Causes of Elevated Anti-CCP Titre
- Rheumatoid arthritis
- Psoriatic arthritis
- Sjögren's syndrome
- Inflammatory myopathies
- Active TB
Pearls
- 70% sensitive and 95% specific for rheumatoid arthritis, therefore a negative test does not rule out RA
- Generally interpreted with rheumatoid factor as the two tests together are more predictive
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