Albumin
September 1st, 2020
Overview
Albumin is a group of serum proteins produced by the liver that maintain oncotic pressure and transport certain hydrophobic compounds.
Normal Range
- 32 - 45 g/L
Albumin has a plasma half-life of three weeks, meaning that its concentration changes very slowly in response to changes in synthesis.
Albumin is a negative acute phase reactant, meaning that its level will fall in the context of acute inflammation. This occurs as a result of reduced hepatic production, as well as proteolysis.
Causes of Hypoalbuminaemia
- Reduced synthesis - malnutrition, malabsorption, liver disease
- Increased breakdown - infection, inflammation, malignancy, hyperthyroidism
- Increased loss - nephrotic syndrome, protein-losing enteropathy, severe burns
- Dilutional
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