Test Findings
 

Vitamin B12 Deficiency

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Overview

    • Look For

    • Reduced Vitamin B12 level
    • Macrocytic, hyperchromic anaemia
    • Hypersegmented neutrophils
    • Manifestations

    • Manifestations
    • Megaloblastic anaemia
    • Atrophic glossitis
    • Peripheral neuropathy
    • Dementia
    • Causes of B12 Deficiency

    • Atrophic gastritis - pernicious anaemia, H pylori infection
    • Malabsorption - coeliac disease, tropical sprue, Crohn's disease, alcohol abuse
    • Surgical resection - gastrectomy, gastric bypass, resection of terminal ileum
    • Pancreatic insufficiency - chronic pancreatitis
    • Inherited disorders - Imerslund-Gräsbeck syndrome
  • Dietary deficiency is rare as a cause of B12 deficiency.
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