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Test Findings
 
 

Vitamin B12 Deficiency

 
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Overview

  • Look For

  • Reduced Vitamin B12 level
  • Macrocytic, hyperchromic anaemia
  • Hypersegmented neutrophils
  • Manifestations

  • Manifestations
  • Megaloblastic anaemia
  • Atrophic glossitis
  • Peripheral neuropathy
  • Dementia
  • Causes of B12 Deficiency

  • Atrophic gastritis - pernicious anaemia, H pylori infection
  • Malabsorption - coeliac disease, tropical sprue, Crohn's disease, alcohol abuse
  • Surgical resection - gastrectomy, gastric bypass, resection of terminal ileum
  • Pancreatic insufficiency - chronic pancreatitis
  • Inherited disorders - Imerslund-Gräsbeck syndrome
Dietary deficiency is rare as a cause of B12 deficiency.
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