Vitamin B12 Deficiency
April 24th, 2019
Overview
Look For
- Reduced Vitamin B12 level
- Macrocytic, hyperchromic anaemia
- Hypersegmented neutrophils
Manifestations
- Manifestations
- Megaloblastic anaemia
- Atrophic glossitis
- Peripheral neuropathy
- Dementia
Causes of B12 Deficiency
- Atrophic gastritis - pernicious anaemia, H pylori infection
- Malabsorption - coeliac disease, tropical sprue, Crohn's disease, alcohol abuse
- Surgical resection - gastrectomy, gastric bypass, resection of terminal ileum
- Pancreatic insufficiency - chronic pancreatitis
- Inherited disorders - Imerslund-Gräsbeck syndrome
Dietary deficiency is rare as a cause of B12 deficiency.
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