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Test Findings

Toxic Granulation of Neutrophils



  • Toxic granulation is present when there is an increase in the number of large basophilic granules within circulating neutrophils.
  • Levels of toxic granulation are highly correlated with C-reactive protein (CRP) values in patients with infection or inflammation.
    • Causes of Toxic Granulation

    • Bacterial infection
    • Inflammation
    • G-CSF
    • Pregnancy
    • Recovery post bone marrow suppression
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