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Thrombocytosis

 
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Overview

Thrombosis refers to an increase in circulating platelets. This may occur due to a myeloproliferative neoplasm, a reactive increase in platelet production, or a shift in platelets from the spleen into the circulation.
  • Causes of Thrombocytosis

  • Primary

  • Myeloproliferative neoplasms - essential thrombocythaemia, polycythaemia vera, chronic myeloid leukaemia, myelofibrosis
  • Increased Production

  • Infection
  • Inflammation - autoimmune disease, major surgery, trauma, fracture, burns, pancreatitis, infarction
  • Malignancy
  • Drugs - adrenaline, corticosteroids, vinca alkaloids, thrombopoietin
  • Acute haemorrhage
  • Iron deficiency
  • Platelet Shift

  • Hyposplenism - splenectomy, liver cirrhosis, coeliac disease, sickle cell disease, SLE
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