Thrombocytosis
April 24th, 2019
Overview
Thrombosis refers to an increase in circulating platelets. This may occur due to a myeloproliferative neoplasm, a reactive increase in platelet production, or a shift in platelets from the spleen into the circulation.
Causes of Thrombocytosis
Primary
- Myeloproliferative neoplasms - essential thrombocythaemia, polycythaemia vera, chronic myeloid leukaemia, myelofibrosis
Increased Production
- Infection
- Inflammation - autoimmune disease, major surgery, trauma, fracture, burns, pancreatitis, infarction
- Malignancy
- Drugs - adrenaline, corticosteroids, vinca alkaloids, thrombopoietin
- Acute haemorrhage
- Iron deficiency
Platelet Shift
- Hyposplenism - splenectomy, liver cirrhosis, coeliac disease, sickle cell disease, SLE
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