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Test Findings
 
 

Thrombocytopaenia

 
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Overview

Reduced circulating platelets.
  • Causes of Thrombocytopaenia

  • Reduced Production

  • Congenital thrombocytopaenia - e.g. May-Hegglin, Bernard-Soulier
  • Bone marrow failure - aplastic anaemia, paroxysmal nocturnal haemoglobinuria
  • Bone marrow suppression - cytotoxic chemotherapy, radiotherapy, alcohol abuse
  • Bone marrow infiltration - leukaemia, multiple myeloma, lymphoma, metastasis, myelofibrosis
  • Myelodysplasia
  • B12 / folate deficiency
  • Increased Destruction

  • Autoimmune thrombocytopaenia - immune thrombocytopaenic purpura (ITP), SLE, antiphospholipid syndrome, rheumatoid arthritis
  • Alloimmune thrombocytopaenia - transfusion reaction
  • Drug-induced immune thrombocytopaenia - heparin-induced thrombocytopaenia (HIT), quinine, bactrim, vancomycin, rifampin, paracetamol, NSAIDs, glycoprotein IIb/IIIa inhibitors
  • Infection - HIV, hepatitis C, EBV, CMV, H pylori, sepsis
  • Thrombotic microangiopathies - thrombotic thrombocytopaenic purpura (TTP), haemolytic-uraemic syndrome (HUS), disseminated intravascular coagulation (DIC), HELLP syndrome
  • Gestation thrombocytopaenia 
  • Splenic Sequestration

  • Hypersplenism
  • Factitious

  • Platelet clumping
  • Haemodilution (e.g. massive transfusion)
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