Test Findings
 

Spherocytosis

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Overview

  • Spherocytes are round cells with loss of central pallor. 
    • Spherocytosis
    • Spherocytosis
       
  • This occurs due to a reduction in the cell membrane size without a reduction in the size of the cytoplasm, which may occur due to direct damage or removal of a portion of the cell membrane by phagocytes.
    • Causes of Spherocytosis

    • Hereditary spherocytosis
    • Immune haemolysis - warm autoimmune haemolytic anaemia, cold agglutinin haemolysis, transfusion reaction, haemolytic disease of the newborn, drug-induced haemolysis
    • Clostridium infection
    • Severe burns
    • Snake bite
  • Red cells have a spherocytoid appearance in the thinner part of the blood film, so it is important to look at a blood film in the area where red cells are first starting to touch.
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