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Spherocytosis

 
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Overview

Spherocytes are round cells with loss of central pallor. 
  • Spherocytosis
  • Spherocytosis
     
This occurs due to a reduction in the cell membrane size without a reduction in the size of the cytoplasm, which may occur due to direct damage or removal of a portion of the cell membrane by phagocytes.
  • Causes of Spherocytosis

  • Hereditary spherocytosis
  • Immune haemolysis - warm autoimmune haemolytic anaemia, cold agglutinin haemolysis, transfusion reaction, haemolytic disease of the newborn, drug-induced haemolysis
  • Clostridium infection
  • Severe burns
  • Snake bite
Red cells have a spherocytoid appearance in the thinner part of the blood film, so it is important to look at a blood film in the area where red cells are first starting to touch.
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