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Test Findings
 
 

Reduced TSH

 
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Overview

A suppressed TSH is suggestive of primary hyperthyroidism.
  • Causes of Reduced TSH

  • Primary Hyperthyroidism

  • Grave's disease
  • Toxic multinodule goitre
  • Toxic nodule
  • Thyroiditis - postviral, postpartum, lymphocytic
  • Drugs - thyroxine, amiodarone, iodine
  • Pregnancy-related - hyperemesis gravidarum, hydatidiform mole
  • Struma ovarii
  • Congenital hyperthyroidism
  • Other

  • Subclinical hyperthyroidism
  • Nonthyroidal illness
  • Central hypothyroidism
  • Congenital TSH or TRH deficiency
  • Interpretation

  • Supressed TSH with elevated T4 - suggestive of primary hyperthyroidism
  • Suppressed TSH with normal T4 - suggestive of subclinical hyperthyroidism
  • Suppressed TSH with reduced T4 - suggestive of nonthyroidal illness or central hyperthyroidism
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