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Test Findings
 
 

Reduced Red Cell Count

 
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Overview

Reduced circulating red blood cells.
  • Causes of Reduced Red Cell Count

  • Reduced RBC Production

  • Haematinic deficiency - B12, folate, iron
  • Bone marrow pathology - aplastic anaemia, myeloproliferative diseases, myelofibrosis
  • Endocrine - EPO deficiency, hypothyroidism
  • Anaemia of chronic disease (infection / inflammation / malignancy)
  • Sideroblastic anaemia
  • Thalassaemias
  • Increased RBC Destruction (Haemolysis)

  • Immune haemolysis - autoimmune, alloimmune, drug-induced
  • Red cell fragmentation - thrombotic microangiopathies, mechanical haemolysis
  • Intrinsic RBC disorders - enzymopathies, membranopathies, haemoglobinopathies
  • Hypersplenism
  • Other - infection, copper, lead, hypophosphataemia
  • RBC Loss

  • Trauma
  • Gastrointestinal bleed
  • Bleeding from another source e.g. urinary tract
  • Factitious

  • Dilutional - excess fluid administration, pregnancy
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