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Test Findings

Reduced Free T4

April 24th, 2019


Reduced T4 with elevated TSH is suggestive of primary hypothyroidism, which normal or reduced TSH may be present with certain conditions or due to false reduction.
  • Causes of Reduced Free T4

  • Elevated TSH

  • Primary hypothyroidism
  • Reduced / Normal TSH

  • Nonthyroidal illness
  • Recent treatment of hyperthyroidism
  • Central hypothyroidism
  • Congenital TSH or TRH deficiency
  • False Reduction

  • Increased TBG - pregnancy, oral oestrogen, SERMs, hepatitis
  • Drugs - aspirin, phenytoin, carbamazepine
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