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Test Findings

Reduced Free T4



  • Reduced T4 with elevated TSH is suggestive of primary hypothyroidism, which normal or reduced TSH may be present with certain conditions or due to false reduction.
    • Causes of Reduced Free T4

    • Elevated TSH

    • Primary hypothyroidism
    • Reduced / Normal TSH

    • Nonthyroidal illness
    • Recent treatment of hyperthyroidism
    • Central hypothyroidism
    • Congenital TSH or TRH deficiency
    • False Reduction

    • Increased TBG - pregnancy, oral oestrogen, SERMs, hepatitis
    • Drugs - aspirin, phenytoin, carbamazepine
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