PT/INR Correction with Mixing

Correction of PT/INR with Mixing

• If the PT/INR is initially elevated but becomes normal when control plasma is added, this suggests that there is factor deficiency as the cause of coagulopathy.
• This occurs commonly in the setting of warfarin or vitamin K deficiency, however may occur in the context of deficiencies affecting multiple pathways.

• • Causes of PT/INR Correction with Mixing

  • Warfarin
  • Vitamin K deficiency
  • Congenital factor deficiency
  • Disseminated intravascular intracoagulation
  • Liver failure