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Leukopaenia

 
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Overview

Leukopaenia refers to a reduction in circulating white blood cells. Leukopaenia is almost always caused by neutropaenia, lymphopaenia, or both.
  • Causes of Leukopaenia

  • Congenital - congenital neutropaenias, primary immunodeficiency disorders
  • Bone marrow pathology -  aplastic anaemia, myelofibrosis, myelodysplasia, acute leukaemia, LGL leukaemia, lymphoma, cancer metastasis
  • Infection - viral, bacterial, rickettsial, fungal, severe sepsis
  • Autoimmune - primary autoimmune neutropaenia, SLE, rheumatoid arthritis (Felty’s syndrome)
  • Drugs (dose-related or idiosyncratic) - cytotoxic chemotherapy, NSAIDs, methotrexate, azathioprine, sulfasalazine, clozapine, many others
  • Dietary deficiency - B12, folate, copper, zinc, alcohol abuse, severe malnutrition
  • Chronic idiopathic neutropaenia
  • Hypersplenism
  • Sarcoidosis
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