Leukopaenia
April 24th, 2019
Overview
Leukopaenia refers to a reduction in circulating white blood cells. Leukopaenia is almost always caused by neutropaenia, lymphopaenia, or both.
Causes of Leukopaenia
- Congenital - congenital neutropaenias, primary immunodeficiency disorders
- Bone marrow pathology - aplastic anaemia, myelofibrosis, myelodysplasia, acute leukaemia, LGL leukaemia, lymphoma, cancer metastasis
- Infection - viral, bacterial, rickettsial, fungal, severe sepsis
- Autoimmune - primary autoimmune neutropaenia, SLE, rheumatoid arthritis (Felty's syndrome)
- Drugs (dose-related or idiosyncratic) - cytotoxic chemotherapy, NSAIDs, methotrexate, azathioprine, sulfasalazine, clozapine, many others
- Dietary deficiency - B12, folate, copper, zinc, alcohol abuse, severe malnutrition
- Chronic idiopathic neutropaenia
- Hypersplenism
- Sarcoidosis
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