Test Findings
 

Leukopaenia

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Overview

  • Leukopaenia refers to a reduction in circulating white blood cells. Leukopaenia is almost always caused by neutropaenia, lymphopaenia, or both.
    • Causes of Leukopaenia

    • Congenital - congenital neutropaenias, primary immunodeficiency disorders
    • Bone marrow pathology -  aplastic anaemia, myelofibrosis, myelodysplasia, acute leukaemia, LGL leukaemia, lymphoma, cancer metastasis
    • Infection - viral, bacterial, rickettsial, fungal, severe sepsis
    • Autoimmune - primary autoimmune neutropaenia, SLE, rheumatoid arthritis (Felty’s syndrome)
    • Drugs (dose-related or idiosyncratic) - cytotoxic chemotherapy, NSAIDs, methotrexate, azathioprine, sulfasalazine, clozapine, many others
    • Dietary deficiency - B12, folate, copper, zinc, alcohol abuse, severe malnutrition
    • Chronic idiopathic neutropaenia
    • Hypersplenism
    • Sarcoidosis
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