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Test Findings
 
 

Left Shift of Neutrophils

 
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Left Shift of Granulocytes

Left shift refers to increased numbers of circulating neutrophil precursors (band forms, metamyelocytes, myelocytes, promyelocytes or even blasts).
This may be physiologic in response to a stress on the body such as pregnancy, infection or inflammation; it may occur with administration of granulocyte colony stimulating factor (G-CSF); or it may be a sign of bone marrow infiltration.
  • Causes of Left Shift of Granulocytes

  • Pregnancy
  • Infection / inflammation
  • G-CSF administration
  • Bone marrow infiltration - MPNS, leukaemias, lymphomas, myeloma, metastatic cancer
The presence of nucleated red blood cells and left shift is referred to as a leukoerythroblastic blood film. If left shift is present then look for nucleated red cells.
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