Test Findings
 

LDH Isoenzyme Abnormalities

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Overview

  • There are five LDH isoenzymes composed of two H (heart) and M (muscle) subunits. The isoenzymes are classified depending on their migration on electrophoresis.
  • The isoenzyme electrophoresis pattern is relatively non-specific, though specific patterns of isoenzyme elevation are classically (yet loosely) associated with certain diseases.
    • Interpretation

    • Elevated LDH1 and LDH2 - myocardial infarction, brain injury, renal pathology, haemolytic or megaloblastic anaemias
    • LDH1 > LDH2 (‘flipped’ LDH) - myocardial infarction
    • Elevated LDH2 and LDH3 - acute leukaemia
    • Elevated LDH3 and LDH4 - splenic or lung pathology
    • Elevated LDH5 - liver or skeletal muscular pathology
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