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Test Findings
 
 

LDH Isoenzyme Abnormalities

 
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Overview

There are five LDH isoenzymes composed of two H (heart) and M (muscle) subunits. The isoenzymes are classified depending on their migration on electrophoresis.
The isoenzyme electrophoresis pattern is relatively non-specific, though specific patterns of isoenzyme elevation are classically (yet loosely) associated with certain diseases.
  • Interpretation

  • Elevated LDH1 and LDH2 - myocardial infarction, brain injury, renal pathology, haemolytic or megaloblastic anaemias
  • LDH1 > LDH2 (‘flipped’ LDH) - myocardial infarction
  • Elevated LDH2 and LDH3 - acute leukaemia
  • Elevated LDH3 and LDH4 - splenic or lung pathology
  • Elevated LDH5 - liver or skeletal muscular pathology
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