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Keratocytes

 
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Keratocytes / Prekeratocytes

Prekeratocytes and keratocytes are blood film findings that are suggestive of oxidative haemolysis.
  • Keratocytes / Prekeratocytes
  • Keratocytes / Prekeratocytes
     
Keratocytes (bite cells) are red cells with a bite-like defect in their membrane. These occur due to phagocytosis of a Heinz body (made up of denatured haemoglobin), leaving a bite in the cell.
  • Keratocytes / Prekeratocytes
     
Prekeratocytes (blister cells) are similar to keratocytes, however retain a sliver of cell membrane - leaving the cell with a defect that resembles a blister.
  • Causes of Keratocytes / Prekeratocytes

  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • Unstable haemoglobins
  • Drug-induced oxidative haemolysis
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