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Test Findings


March 4th, 2023


Hyperchromia refers to an increase in the intensity of red blood cell colour. Hyperchromic cells may be spherocytes, microspherocytes or macrocytes.
  • Hyperchromia
  • Signs of Hyperchromia

  • Reduction in central pallor on blood film
  • Increased red cell haemoglobin (MCH / MCHC)
  • Causes of Hyperchromia

  • Spherocytosis - hereditary spherocytosis, immune haemolysis, Clostridium
  • Microspherocytosis - microangiopathic haemolytic anaemia, severe burns
  • Macrocytosis - B12/folate deficiency chronic liver disease, alcohol abuse, hypothyroidism, post splenectomy, aplastic anaemia, myelodysplastic syndrome
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