Hyperchromia
Overview
Hyperchromia refers to an increase in the intensity of red blood cell colour. Hyperchromic cells may be spherocytes, microspherocytes or macrocytes.
Signs of Hyperchromia
- Reduction in central pallor on blood film
- Increased red cell haemoglobin (MCH / MCHC)
Causes of Hyperchromia
- Spherocytosis - hereditary spherocytosis, immune haemolysis, Clostridium
- Microspherocytosis - microangiopathic haemolytic anaemia, severe burns
- Macrocytosis - B12/folate deficiency chronic liver disease, alcohol abuse, hypothyroidism, post splenectomy, aplastic anaemia, myelodysplastic syndrome
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