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Test Findings
 
 

Howell Jolly Bodies

 
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Overview

Howell Jolly bodies are basophilic inclusions within the cytoplasm, made up of DNA fragments.
  • Howell Jolly Bodies
  • Howell Jolly Bodies
     
Howell Jolly bodies are classically seen following splenectomy, though may also occur in patients with any cause of hyposplenism.
  • Causes of Howell Jolly Bodies

  • Post-splenectomy
  • Functional hyposplenism - sickle cell anaemia, liver cirrhosis, SLE, rheumatoid arteritis, coeliac disease, inflammatory bowel disease, splenic artery / vein thrombosis, amyloidosis, sarcoidosis 
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