Howell Jolly Bodies
March 30th, 2020
Overview
Howell Jolly bodies are basophilic inclusions within the cytoplasm, made up of DNA fragments.
Howell Jolly bodies are classically seen following splenectomy, though may also occur in patients with any cause of hyposplenism.
Causes of Howell Jolly Bodies
- Post-splenectomy
- Functional hyposplenism - sickle cell anaemia, liver cirrhosis, SLE, rheumatoid arteritis, coeliac disease, inflammatory bowel disease, splenic artery / vein thrombosis, amyloidosis, sarcoidosis
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