Test Findings
 

Howell Jolly Bodies

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Overview

  • Howell Jolly bodies are basophilic inclusions within the cytoplasm, made up of DNA fragments.
    • Howell Jolly Bodies
    • Howell Jolly Bodies
       
  • Howell Jolly bodies are classically seen following splenectomy, though may also occur in patients with any cause of hyposplenism.
    • Causes of Howell Jolly Bodies

    • Post-splenectomy
    • Functional hyposplenism - sickle cell anaemia, liver cirrhosis, SLE, rheumatoid arteritis, coeliac disease, inflammatory bowel disease, splenic artery / vein thrombosis, amyloidosis, sarcoidosis 
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