Test Findings
 

Folate Deficiency

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Overview

    • Look For

    • Reduced serum red cell folate levels
    • Macrocytic, hyperchromic anaemia
    • Hypersegmented neutrophils
    • Manifestations

    • Megaloblastic anaemia
    • Neural tube defects (deficiency during pregnancy)
    • Increased cardiovascular risk
    • Dementia
    • Causes of Folate Deficiency

    • Nutritional deficiency - poor intake, alcohol abuse
    • Malabsorption - coeliac disease, inflammatory bowel disease, jejunal resection
    • Increased requirement - pregnancy, malignancy
    • Impaired metabolism - methotrexate, trimethoprim
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