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Test Findings

Folate Deficiency

April 24th, 2019


  • Look For

  • Reduced serum red cell folate levels
  • Macrocytic, hyperchromic anaemia
  • Hypersegmented neutrophils
  • Manifestations

  • Megaloblastic anaemia
  • Neural tube defects (deficiency during pregnancy)
  • Increased cardiovascular risk
  • Dementia
  • Causes of Folate Deficiency

  • Nutritional deficiency - poor intake, alcohol abuse
  • Malabsorption - coeliac disease, inflammatory bowel disease, jejunal resection
  • Increased requirement - pregnancy, malignancy
  • Impaired metabolism - methotrexate, trimethoprim
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