ENA
Overview
- Extractable nuclear antigens (ENA) are a subset of antinuclear antibodies (ANA) that are directed against nuclear antigens.
- Certain antibodies are particular associated with specific autoimmune disorders.
Lupus & Sjogren's
- Anti-SSa / RoSjogren's syndrome, SLE
- Anti-SSb / LaSjogren's syndrome, SLE
- Anti-Sm (Smith)Highly suggestive of SLE; particularly renal and CNS involvement
- Anti-HistoneSLE, drug-induced lupus
Mixed Connective Tissue Disease
- Anti-RNPMixed connective tissue disease, scleroderma
Scleroderma
- Anti-CentromereLimited scleroderma
- Anti-SCL-70 (DNA topoisomerase I)Diffuse scleroderma; increased risk of interstitial lung disease
- Anti-RNA polymerase III (RNApol3)Severe cutaneous scleroderma; increased risk of scleroderma renal crisis
- Anti-Th/ToScleroderma; increased risk of pulmonary hypertension
- Anti-RNPMixed connective tissue disease, scleroderma
- Anti-PM-SCLScleroderma / inflammatory myositis crossover
- Anti-KuScleroderma / inflammatory myositis crossover
Inflammatory Myositis
- Anti-Mi-2Dermatomyositis
- Anti-Jo-1Dermatomyositis, antisynthetase syndrome
- Anti-HMG CoA reductaseNecrotising myopathy
- Anti-MDA5Dermatomyositis with interstitial lung disease
- Anti-PM-SCLScleroderma / inflammatory myositis crossover
- Anti-KuScleroderma / inflammatory myositis crossover
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