Test Findings
 

Elevated LDH

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Overview

  • LDH is elevated in haemolysis, and markedly in intravascular haemolysis.
  • As LDH is present in all tissues, its elevation is a nonspecific marker of cell damage. Elevation of specific LDH isoenzymes may point toward a specific pathology, as below.
    • Causes of Elevated Lactate Dehydrogenase

    • Factitious (haemolysed sample)
    • Heart - myocardial infarction, heart failure
    • Brain - ischaemic stroke, traumatic brain injury
    • Kidneys - nephritis, nephrotic syndrome, acute tubular necrosis, infarction
    • Anaemia - haemolytic or megaloblastic
    • Malignancy (especially haematological)
    • Lungs - pulmonary embolism, infarction, obstructive disease, interstitial lung disease, pneumonia
    • Spleen - infarction
    • Pancreas - pancreatitis
    • Liver - hepatitis, infarction, cirrhosis, malignancy, trauma
    • Skeletal muscle - strenuous exercise, rhabdomyolysis, myositis
    • Shock
    • Trauma
    • Hypoxia
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