Test Findings
 

Elevated CRP

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Overview

  • C-reactive protein is an acute phase protein that is involved in innate immunity, and is responsible for activating the complement pathway.
      • Normal Range

      • <5 mg/L
    • Causes of Elevated CRP

    • Infection - especially bacterial
    • Inflammatory disease - e.g. polymyalgia rheumatica, IBD, vasculitis, rheumatoid arthritis, seronegative arthritides
    • Tissue necrosis - e.g. myocardial infarction, pancreatic necrosis
    • Pearls

    • Elevated CRP is indicative of an active inflammatory state.
    • Serum CRP rises rapidly, with a maximal concentration reached within two days; it falls quickly once inflammation has resolved.
    • CRP has little efficacy as a screening tool for inflammation.
    • The trend in CRP is useful for monitoring resolution or progression of an inflammatory process.
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