Test Findings
 

Elevated Creatinine

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Overview

  • Elevated serum creatinine is most commonly used as a marker of renal injury, though it is important to remember other causes. Patients who have recently eaten meat or who are undergoing muscle breakdown may have an elevated creatinine that gives a false indication of their true renal function. Certain medications (particularly trimethoprim) can elevate the creatinine without causing renal failure.
    • Causes of Elevated Creatinine

    • Renal Failure

    • Acute kidney injury
    • Chronic kidney disease
    • Other Causes

    • Creatinine intake - cooked meat
    • Muscle breakdown - body building, rhabdomyolysis
    • Reduced creatinine secretion - trimethoprim, ranitidine
    • Assay interference - ketosis, hyperbilirubinaemia, cefoxitin
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