Cholestatic LFT Derangement
April 24th, 2019
Overview
Look For
- Elevated ALP and GGT
- Mildly elevated ALT / AST
- Elevated conjugated bilirubin
Causes of Cholestasis
Intrahepatic Cholestasis
- Hepatitis (viral or alcoholic)
- Autoimmune liver disease - primary biliary cirrhosis, primary sclerosing cholangitis
- Infiltrative liver disease - amyloidosis, sarcoidosis, tuberculosis, lymphoma
- Malignancy - hepatocellular carcinoma, cholangiocarcinoma, metastasis
- Non-malignant mass - abscess, cystic liver disease, haematoma
- Sepsis
- Acalculous cholecystitis
- Intrahepatic cholestasis of pregnancy
- Total parenteral nutrition
- Drugs - augmentin, isoniazid, rifampicin, chlorpromazine
Extrahepatic Cholestasis
- Choledocholithiasis
- Bile duct stricture
- Parasitic infection of bile duct
- Primary sclerosing cholangitis
- Pancreatitis
- Pancreatic cyst
- Malignancy - pancreas, ampulla, common bile duct, gallbladder
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