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Test Findings
 
 

Cholestatic LFT Derangement

 
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Overview

  • Look For

  • Elevated ALP and GGT
  • Mildly elevated ALT / AST
  • Elevated conjugated bilirubin
  • Causes of Cholestasis

  • Intrahepatic Cholestasis

  • Hepatitis (viral or alcoholic)
  • Autoimmune liver disease - primary biliary cirrhosis, primary sclerosing cholangitis
  • Infiltrative liver disease - amyloidosis, sarcoidosis, tuberculosis, lymphoma
  • Malignancy - hepatocellular carcinoma, cholangiocarcinoma, metastasis
  • Non-malignant mass - abscess, cystic liver disease, haematoma
  • Sepsis
  • Acalculous cholecystitis
  • Intrahepatic cholestasis of pregnancy
  • Total parenteral nutrition
  • Drugs - augmentin, isoniazid, rifampicin, chlorpromazine
  • Extrahepatic Cholestasis

  • Choledocholithiasis
  • Bile duct stricture
  • Parasitic infection of bile duct
  • Primary sclerosing cholangitis
  • Pancreatitis
  • Pancreatic cyst
  • Malignancy - pancreas, ampulla, common bile duct, gallbladder
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