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Test Findings

APTT Non-Correction with Mixing


Non-Correction of APTT with Mixing

  • If the APTT remains elevated despite addition of control plasma, this suggests that there is an inhibitor present.
  • This occurs commonly in the context of heparin, though may also occur with antiphospholipid syndrome.
    • Causes of APTT Non-Correction with Mixing

    • Heparin
    • Factor IIa inhibitors (e.g. dabigatran)
    • Lupus anticoagulant
    • Specific factor inhibitors
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