APTT Non-Correction with Mixing
Non-Correction of APTT with Mixing
- If the APTT remains elevated despite addition of control plasma, this suggests that there is an inhibitor present.
- This occurs commonly in the context of heparin, though may also occur with antiphospholipid syndrome.
Causes of APTT Non-Correction with Mixing
- Heparin
- Factor IIa inhibitors (e.g. dabigatran)
- Lupus anticoagulant
- Specific factor inhibitors
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